In 2014, President Obama signed the Farm Bill of 2014 into law. This law contained a section that removed hemp from Schedule 1 of the Controlled Substances Act. It also created a legal structure that made cultivation and research of hemp legal in states that wanted to initiate “Pilot Research Programs” into the cultivation and marketing of hemp and hemp-derived products.
Understanding CBD’s analgesic, or pain-relieving, interactions with the ECS can shed light on CBD’s other interactions and effects. Importantly, the ECS participates in our bodies’ pain processing, but when CBD is introduced to our ECS, it stops the body from absorbing a pain-regulating compound known as anandamide — one of our body’s’ own natural cannabinoid molecules. Inhibiting the absorption of this compound shunts excess quantities into the bloodstream that in turn reduces pain. One study has revealed that CBD targets alpha-3 (α3) glycine receptors to suppress chronic pain and inflammation associated with dysfunctional glycine receptors, which are an important target for pain processing in the spine. In both humans and animal models, CBD has been shown to have a variety of anti-inflammatory properties.
As noted in the previous section, CBD oil prices vary significantly by brand. The best practice for most is to determine a per-milligram budget for CBD oil, as well as a maximum price for the entire bottle. For example, you might decide that 10 cents per milligram or less is a reasonable budget; and that $45 (for a 450-mg concentration, based on the budget) is a maximum bottle price. Also, if ordering online, be sure to include potential shipping costs.
Laboratory evidence indicated that cannabidiol may reduce THC clearance, increasing plasma concentrations which may raise THC availability to receptors and enhance its effect in a dose-dependent manner.[24][25] In vitro, cannabidiol inhibited receptors affecting the activity of voltage-dependent sodium and potassium channels, which may affect neural activity.[26] A small clinical trial reported that CBD partially inhibited the CYP2C-catalyzed hydroxylation of THC to 11-OH-THC.[27]
Hemp oil cold pressed from hemp seeds grown in Canada. This hemp oil is also from an industrial hemp variety of Cannabis sativa which doesn’t require herbicides, pesticides, and fertilizers. Hemp oil is very nutritious with an ideal profile of omega 3 and 6, but the main purpose for it being in our blend is to have a base oil to emulsify the hemp extract into.
So totally blown away by Medterra CBD oil. I have taken other brands and nothing compares to Medterra. I like that it is certified THC free and grown and manufactured right here in the U.S. The shipping was very reasonable and I received my oil within about 4-5 days. They also offer a 30 day money back guarantee if I decide to return. ( but I won’t!!!). You can’t go wrong with Medterra for your joint and body aches. I’m finally able to sleep at night again!! Thank you Medterra !!!!
There’s also the cost factor: Chronic use of CBD oil can be costly and less effective against microbes compared to alternative antimicrobial herbs like Japanese knotweed, cat’s claw, andrographis, garlic, sarsaparilla, and berberine. The bottom line is, CBD oil is a good option for controlling symptoms associated with Lyme disease, fibromyalgia, and other chronic illnesses, but it should be combined with other antimicrobial and immunomodulating herbs for optimal benefit. CBD oil is best used intermittently to treat symptoms of pain or anxiety, or used chronically only until symptoms gradually resolve, and then discontinued.
You then take your first drop of CBD oil, wait 45 minutes, then ask the questions again. If you feel no different and there’s no change in the way you answer those questions, you increase the dose by small increments until you do notice a difference. You can continue this process over several days – and at some point, you’ll find that taking more doesn’t change your scores. That is your minimum effective dose.
What makes CBD so appealing is that it’s non-intoxicating, so it won’t get you high, though it “is technically psychoactive, because it can influence things like anxiety,” Jikomes said. Although much of the marketing blitz around CBD centers on the fact that you can take it without getting stoned, there isn’t much research looking at the effects of CBD when used in isolation, with a couple of exceptions. One is the use of CBD to treat seizures: CBD is the active ingredient in the only cannabis product that the Food and Drug Administration has signed off on — a drug called Epidiolex, which is approved for treating two rare forms of epilepsy. Animal models and a few human studies suggest that CBD can help with anxiety, but those are the only conditions with much research on CBD in isolation.

As Vox’s German Lopez notes, the move toward hemp legalization is less about removing the stigma of cannabis than about the economic benefits of legalizing marijuana. Hemp’s legalization will give farmers a major opportunity with a new and friendly crop. According to Leafly, the hemp plant “detoxifies the soil and prevents soil erosion,” and it “requires much less water to grow — and no pesticides — so it is much more environmentally friendly than traditional crops.”
Your post indicates a difference between hemp oil (which you said is from seeds) and hemp extract (which there doesn’t seem to be much information about on your site) and that your all recommend hemp extract. The links you post for hemp extract link to products labeled at hemp oil and as containing hemp oil. My question: are your products derived from hemp seeds, full plant extraction, or a cbd isolation/extraction process? Thanks!!
^ Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, Stadelmann AM (December 2005). "Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract". Ther Drug Monit. 27 (6): 799–810. PMID 16306858.
This article may contain certain forward-looking statements and information, as defined within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, and is subject to the Safe Harbor created by those sections. This material contains statements about expected future events and/or financial results that are forward-looking in nature and subject to risks and uncertainties. Such forward-looking statements by definition involve risks, uncertainties.
Chronic pain: The body’s ECS plays a role in alleviating and managing pain, so CBD oil can work as a supplement for individuals with medical conditions that cause chronic pain, such as arthritis and multiple sclerosis. CBD oil also increases levels of adenosine in the brain; adenosine is a neurotransmitter that aids cardiovascular function and eases painful inflammation.
It should be noted that recreational use of marijuana (high THC, low CBD cannabis) does result in dependence (but different from narcotics or alcohol, and not as debilitating). Chronic use of THC may be associated with atrophy in certain areas of the brain and reduction of certain cognitive functions (at this point, studies are not conclusive). Interestingly, studies have shown that taking CBD oil regularly can restore areas of the brain that have become atrophied in marijuana abusers. 

AC/DC: A Sativa-dominant phenotype of Cannatonic, this cultivar boasts one of the highest ratios of CBD to THC, clocking in at 20:1. AC/DC is claimed to help reduce pain, anxiety, depression and migraines while reducing symptoms in patients with epilepsy, some forms of cancer, and multiple sclerosis. This cultivar’s pinene-rich terpene profile offers potent clear-headed pain relief. 

REM behavior disorder: REM behavior disorder (RBD) is a parasomnia disorder characterized by shouting, becoming physically agitated, or otherwise acting out during sleep. For many, RBD is a symptom of a larger, more serious condition or disorder, such as Alzheimer’s disease or PTSD. CBD oil minimizes the symptoms of RBD, and also alleviates the anxiety and painful symptoms that often accompany disorders that lead to RBD.

The dosages mentioned do not take into account the strength of the tincture. I have Elixinol 300, I took 1/2 dropper (0.5ml, which offers 5mg of CBD) as indicated on the bottle and felt severely nauseous for 3 hours thereafter. There is no way I cold take this dose twice per day, as recommended on the bottle. The high dosages on this site must surely be for much weaker concentrations?

There are two main types of receptors in the ECS, CB1 and CB2. CB1 receptors are primarily located in the central nervous system and brains of mammals, and CB2 are generally found in the peripheral nervous system. There are two main cannabinoids mammals produce- 2AG and Anandamide (named after the Sanskrit term “Ananda,” which translates to “peace”).
CBD is short for cannabidiol, and it is one of more than 60 compounds found in these plants.  It acts on the body’s endocannabinoid system, creating physical changes in the body, which can be beneficial in many ways.  In recent times, it has become increasingly understood that taking CBD oil, a product made from CBD, can have a positive influence on many aspects of life and health.
However it’s classified, Cannabis ruderalis is naturally low in cannabinoids. Its real value lies in its genetics. While Cannabis indica and sativa flower based on how much light they get (the photoperiod), Cannabis ruderalis is what’s called an autoflowering strain. That means it reaches maturity—usually in 20 to 30 days—regardless of the light cycle.
Keep in mind that CBD levels may vary from crop to crop—even from plant to plant. However, below are some strains that have been bred to contain higher CBD levels, so they might be a good place to start. Check the map on their strain page to see if these are sold at a dispensary near you. We also recommend checking with dispensaries about the specifics of their strains’ CBD levels. It’s always a good idea to purchase only lab-tested products that clearly state the CBD/THC levels so you know what kind of experience to expect.

These products are from places like Xi’an Lyphar Biotech Co. Ltd., which doesn’t mention that it’s one of the largest CBD sellers on Alibaba on its website, let alone reveal where it’s sourcing its CBD from. There are big companies and small companies, companies that provide elaborate chemical charts and companies that have no online presence at all. There are companies that run their goods — either as raw materials or as consumer-stage final products — through lab tests. There are those that say they do but provide no information on what the labs found or which labs tested their products.


Management of chronic pain is another application for which CBD is ideally suited, and it works in a number of ways. It and other non-THC cannabinoids found in hemp flower-bud extracts work to block pain-conducting nerve impulses, which reduces your perception of pain. Stimulation of CB1 in the brain increases dopamine, which counteracts pain. Just as importantly, these same chemical substances reduce inflammation, the driving force behind pain, which allows healing to occur.


The main difference between the three Original Blends is the additional herbal ingredients besides hemp. We suggest you research the separate components of each blend to determine which product may be most appealing to add to your dietary regimen. If you know it’s solely the hemp extract that you are looking for, with no additional ingredients, then Classic Hemp Blend or Classic Hemp 6x is what you’re looking for.

CBD Cream

×