But Kase acknowledges that her CBD suggestions should not be confused with medical advice. Much like with her yoga instruction, she says that she is only sharing what has worked for her in the hopes that it will help others. “I don’t say, ‘I recommend and advise that you take ten drops, three times a day,’” she explained. “I say, ‘This is the particular brand that I use. You could try it and see if it helps.’ And people have told me that it does.”

The skin has the highest amount and concentration of CB2 receptors in the body. When applied topically as an infused lotion, serum, oil, or salve, the antioxidant (a more powerful antioxidant than vitamins E and C)[194] in CBD oil has many benefits and can repair damage from free radicals like UV rays and environmental pollutants. Cannabinoid receptors can be found in the skin and seem to be connected to the regulation of oil production in the sebaceous glands.[195] Cannabis-based topical products are being developed to treat related issues from acne to psoriasis and can promote faster healing of damaged skin. In fact, historical documents show that cannabis preparations have been used for wound healing in both animals and people in a range of cultures spanning the globe and going back thousands of years. The use of concentrated cannabis and CBD oils to benefit and treat skin cancer is gaining popularity with a number of well-documented cases of people curing both melanoma and carcinoma-type skin cancers with the topical application of CBD and THC products. Best known is the case of Rick Simpson, who cured his basal cell carcinoma with cannabis oil and now has a widely distributed line of products. Cannabis applied topically is not psychoactive.

Naturally, scientists wanted to see if CBD oil had any anticancer properties. As a result, they performed several animal studies using it. However, it should be noted that the findings don’t fully apply to humans. In fact, they merely suggest what possible effects CBD might have when it comes to dealing with cancer. With that in mind, additional human studies would help conclude if CBD oil has an effect on cancer cells in humans.
Medterra is the only CBD brand I order from. I was a little skeptical about CBD at first but tried it on the advice of my doctor. I suffer from chronic pain and the only thing that helps the pain is this oil. It really helps with my back pain and I use the tincture and the new Cooling Cream. And the best part is that there are no side effects I dont feel drowsy or unfocused and it doesnt interact with other medications. And Medterra is a fantastic company. One time the shipping of my oil was delayed for some reason and they sent it using express shipping without an added cost Their service is great.
The Cannabis Health Index (CHI) is an evidence-based scoring system for cannabis (in general, not just CBD effects) and its effectiveness on various health issues based on currently available research data. Refer to cannabishealthindex.com for updated information. Using this rubric and based on twenty-one studies, cannabis rated in the possible-to-probable range of efficacy for treatment of depression.
The body of research on cannabidiol, CBD oil benefits, THC, and other cannabinoids has grown exponentially in the past decade. The following brings together the latest scientific studies and stories from patients and doctors with advice on treating specific symptoms. It also includes dosage suggestions and information on recommended types of cannabinoid-based medicines for the particular condition.

Cannabidiol, or CBD for short, is a phyto-cannabinoid found in cannabis plants. However, it does not cause the same psychoactive effects as other naturally occurring cannabinoids (such as tetrahydrocannabinol, or THC). CBD induces feelings of sleepiness and tranquility, making it suitable for insomnia and other sleep disorders; CBD can be used to alleviate symptoms of epilepsy, diabetes, and anxiety disorders, as well. Legality is an issue for some; all 50 states have laws governing the sale, possession, and use of CBD, and they vary significantly (see the table below for a full analysis).
The CBD oil we offer has a couple different applications. You can hold a sublingual dose under the tongue for 30-60 seconds (recommended for fastest absorption), apply the oil topically to your skin (can be applied directly to a problem area or mixed with your favorite moisturizer), or blend the oil in a health-conscious smoothie. We will include further dosing instructions with the product.
To calculate the cost per milligram of CBD, simply divide the dollar amount of the product by the total milligrams of CBD in the bottle. So for instance, a product with 600 mg CBD in a 1 fluid-ounce bottle costing $80 is equal to about 13 cents per mg of CBD; a product with 100 mg of CBD in the same size bottle selling for $40 works out to 40 cents per mg of CBD. In this case, it pays to splurge on the $80 bottle.
[185] Ronen Durst, Haim Danenberg, Ruth Gallily, Raphael Mechoulam, Keren Meir, Etty Grad, Ronen Beeri, Thea Pugatsch, Elizabet Tarsish, and Chaim Lotan, “Cannabidiol, A Nonpsychoactive Cannabis Constituent, Protects against Myocardial Ischemic Reperfusion Injury,” American Journal of Physiology – Heart and Circulatory Physiology 293, no. 6 (2007): H3602–H3607. doi:10.1152/ajpheart.00098.2007.
Bonn-Miller also explained that it's imperative to exhaust the traditional and established front-line treatments that are available before seeking out these products. "CBD is not really a first-line treatment for anything," he said. "You don’t want situations where somebody says, 'I have cancer I'm going to forgo chemotherapy because I read something about CBD or THC helping with cancer.'" That's not a good idea, Bonn-Miller said. "Not only is the science not there, but you may end up worse off."
The limited studies out there indicate that CBD has, in its various interactions with the brain and immune system, some anti-inflammatory and anti-anxiety effects. It can balance out the effects of THC by reducing the anxiety THC sometimes brings, and many in the industry are big on “broad spectrum” or “full spectrum” configurations, which use many cannabinoids at once.
Even though, thanks to the Farm Bill, hemp lost its status as a Schedule I drug – one that has no proven medical purpose and potential for abuse – marijuana did not. That means even though many states have legalized its use, the federal government still considers marijuana and CBD products derived from marijuana in almost any form to be illegal. But so far, federal law enforcement officials have not used their power to swoop in and shut down marijuana operations in states that have legalized it.
For ingested CBD, that fat solubility is a problem. “[Ingested] CBD has a very low bioavailability, something between 6 and 15 percent, which varies between people,” says Blessing. Because ingested CBD is so inefficient at actually getting to the brain to stimulate CB1 and other receptors, the doses shown to be effective have to be very high. “There’s no evidence that doses below 300 mg of CBD have any effect in any psychiatric measure,” says Blessing. “And in fact, dose-finding studies show that the lowest clinically effective dose of CBD for reducing anxiety is 300 mg.” Blessing is talking about induced anxiety in otherwise healthy patients, which is all we have studies on; studies of CBD’s efficacy in treating clinical anxiety, which would require regular doses, haven’t been published.
When considering our different dietary hemp products, know that they all come in two strengths. Our Original Hemp blends (Hemp Classic, Hemp Complete, & Signature Blend) all have 250+mg of cannabinoids per fluid ounce, and our concentrated blends have 1,500+mg per fluid ounce, six times the potency of our traditional oils. We’ve found that sometimes less is more, but nevertheless, some people like to take very large serving sizes of our hemp extracts.
Clancy says his dose estimates are based on a book called CBD: A Patient’s Guide to Medicinal Cannabis: Healing Without the High. The co-author of that book is Leonard Leinow, the founder of Synergy Wellness, which calls itself a “hand crafted artisanal CBD cannabis collective.” He is not a doctor or a scientist, but he is a sculptor of erotic bronze pieces, like a yin-yang symbol made up of two interlocking penises.
Here, the evidence is not going to make them happy. A 2017 study in JAMA reported that only 26 of 84 samples of CBD oils, tinctures and liquids purchased online contained the amount of CBD claimed on their labels. Eighteen of them contained THC, which could lead to intoxication or impairment in some individuals. And a quarter had less CBD than advertised. The F.D.A. has likewise found many products that did not contain the amount of CBD they were claiming.

The Cannabis Health Index (CHI) is an evidence-based scoring system for cannabis (in general, not just CBD effects) and its effectiveness on various health issues based on currently available research data. Refer to cannabishealthindex.com for updated information. Using this rubric and based on twenty-one studies, cannabis rated in the possible-to-probable range of efficacy for treatment of depression.
Outside of the aforementioned studies, CBD’s progress toward its place in society today suffered from intermittent spurts and starts until 1996 when California became the first US state to legalize medical cannabis. This groundbreaking moment paved the way for public support and lucrative research opportunities. Other states including Oregon, Alaska, Washington, Maine, Hawaii, Nevada, and Colorado would follow suit before the close of 2000.
As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.
CBD vaporizer oils can be used in a vaporizer of your choice. They offer a healthy way of inhaling your daily dose of the CBD supplement. Vaping is a very direct way of ingesting CBD oil. When you vape, the CBD enters the lungs and goes directly into the bloodstream, completely bypassing the digestive system. This method allows for greater bioavailability.

CBD has some other very important jobs outside of the endocannabinoid system (ECS). For instance, CBD mildly activates one of the brain’s predominant serotonin receptors (5-HT1A), which may explain CBD’s effects on depression and anxiety. It also acts at the peroxisome proliferator activated receptors (PPARs), which halt the proliferation of cancer cells and convey neuro- and cardioprotection. By interacting with a particular PPAR (gamma), CBD could prove to be a promising new way to prevent alzheimer’s disease and other brain disorders.

Cooper recently got funding from the National Institutes of Health for a study looking at cannabinoids — including CBD in isolation — as a substitute for opioids, and numerous other clinical trials of CBD are underway. It will be several years before results are available, but these studies should help clarify both what benefits the substance may provide and any side effects it may come with. Most of the adverse effects so far associated with cannabis, such as impairments in short-term memory, coordination and judgment,2 come from products that contain THC as well as CBD, Cooper said, but we need to do more studies to find out for sure whether CBD has fewer risks. Studies are also needed to identify the best way to administer and dose CBD. “I get emails from people asking me what dose of CBD to use, and the truth is, we really don’t know,” Cooper said.
Therefore, ingesting 2,000 mg of CBD oil daily would result in a maximum consumption of 6 mg of THC, which would cause a positive marijuana urine test approximately 23 percent of the time. It’s important to keep in mind the amount of CBD consumed. Although unlikely, it is possible for those who take CBD to fail drug tests if they are taking unusually high doses.

Cannabidiol (CBD) is one of dozens of non-psychoactive cannabinoids found in the hemp plant. Cannabidiol, and all the other cannabinoids, were patented by the United States Government in 2003 as neuroprotectants and antioxidants (Patent No. 6,630,507). Cannabinoids are characterized by their ability to act on the cannabinoid receptors that are found throughout the body. CBD and other cannabinoids are naturally occurring compounds that display potent anti-inflammatory and pain-relieving properties. They can promote the body’s healthy regulation of the central nervous, immune, and endocannabinoid systems.


Your post indicates a difference between hemp oil (which you said is from seeds) and hemp extract (which there doesn’t seem to be much information about on your site) and that your all recommend hemp extract. The links you post for hemp extract link to products labeled at hemp oil and as containing hemp oil. My question: are your products derived from hemp seeds, full plant extraction, or a cbd isolation/extraction process? Thanks!!
“It is important to remember that CBD benefits and improves the activity in the endocannabinoid system by increasing the time anandamide works on the CB1 and CB2 receptors,” writes Dr. Michael Moskowitz. “Anandamide works on the serotonin, norepinephrine, and dopamine systems. It also works on the GABA-glutamate system and the hypothalamic-pituitary-adrenal axis. Its main role is restoring balance through inhibition when levels are too high and enhancement when they are too low. This is the most likely reason phytocannabinoids in general and CBD specifically are able to regulate depression and anxiety.”[321]
The first step to finding your correct CBD dosage is getting as much information as you can about the product you’re using. What is the concentration of CBD? Are there third-party lab tests that can confirm that? The CBD industry is still mainly a grassroots therapeutic movement, and as such, largely unregulated. Concentration and purity levels can differ greatly depending on the manufacturing process.  

Zuardi, A. W., Crippa, J. A., Hallak, J. E., Bhattacharyya, S., Atakan, Z., Martin-Santos, R., … & Guimarães, F. S. (2012). A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation [Abstract]. Current Pharmaceutical Design, 18(32), 5,131–5,140. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22716160
In point of fact, while there is NO third party organic certification system available for marijuana at present, hemp qualifies for organic certification. We extract our CBD rich hemp oil from certified organic Cannabis sativa grown in Europe. Our CBD oil is extracted using supercritical CO2, the cleanest possible processing system. In the US, we are NOT permitted to obtain USDA NOP Organic certification for our product itself, due to our use of CBD rich hemp oil. (This is a decision made by the US government’s organic program, that operates under the umbrella of the USDA, despite the legality of hemp and cannabinoid rich hemp oil.)
Hemp oil can come from the flower, leaves, stock or seeds. If it comes from the seed there are no cannabinoids found. If it comes from the rest of the plant cannabinoids are found. Hemp extract usually refers to either CBD or oil from the stock, flower, or leaves. Our Virgin cannabis sativa hemp oil is a hemp seed oil, and our Premium hemp oil products, have hemp oil from the stem of the plant (which is listed in milligrams on the bottle) It also has hemp seed oil in the bottle to act as a carrier oil. Our Hemp seed oil is a cold pressed seed oil, and our Premium hemp oil that comes from the stem is Co2 extracted.

I purchased the 500 mg tincture to start. I make CBD but I use a different process that does not extract like the CO2 method The CO2 method is the best and you have to be careful when choosing CBD. Make sure that its organic NO GMO and grown in the USA I love how clear it is although it does have a little bit of cloudiness but this is normal. I have been using CBD to relieve anxiety I am agoraphobic and part of that is severe panic attacks. With my first 1 ML dose as soon as it came in the mail today I was starting to relax. I am only guessing but I will probably be taking 1 ML twice per day since this is the 500mg bottle once when I get up and once before bed so this bottle will not last me a month. If it works as well as expected especially after the first dose this morning then I will probably move up to the 1000 mg which will last me the month. One other thing you may have already read this information but this CBD has 0 THC. Thats important for those who work in professions that can not risk having high THC levels no pun intended.What makes me so confident in this product is how fast it worked. 1 ML under the tongue is the best way in my opinion to get the CBD oil to act quickly. This product gets great reviews for pain as well. Fortunately I dont suffer pain just anxiety and panic attacks. Thank you Medterra PS. I was not paid for this review LOL. I paid full price for this product and happy to do it.If Im able I will update this review if needed when I finish this bottle. Or leave another when I get the 1000 mg.
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