^ Jump up to: a b c d Boggs, Douglas L; Nguyen, Jacques D; Morgenson, Daralyn; Taffe, Michael A; Ranganathan, Mohini (6 September 2017). "Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol". Neuropsychopharmacology. 43 (1): 142–154. doi:10.1038/npp.2017.209. ISSN 0893-133X. PMC 5719112. PMID 28875990.
I have found after trying several different brands, MedTerra is the most potent, consistent and competitively priced product on the market. Being able to purchase it by mail order is also very convenient. One thing I noticed on other brands is there seems to be confusion over the actual dosage. Folks see 500 mg on the bottle and think they are taking a 500 mg dose. Incorrect! That is the total mg CBD per bottle. One brand for example states on the 2 oz bottle, 60ml-500mg. That breaks down to 8.333mg per ml. But it was only 60% purity which translates to only 5 mg per 1 ml dose. (500mg / 60 ml = 8.3333 mg per ml, at 60 % purity 8.3333 * .6 = 5 mg per ml dose.) I have not seen anyone break it down correctly until I looked at MedTerra. They dont mess around. You get 99% pure product, period. This allows more accurate dosage than other companies, giving YOU more control and confidence using their products. Pain and inflammation greatly reduced, I sleep better, mood and blood sugar leveled out, reduced appetite. Thank you MedTerra! Word of mouth is the best advertisement! All CBD Tinctures, regardless of strength, are 1 fluid oz and contain 30 servings at 1 ml each. The dropper in the cap has measurement markers of .25, .5, .75 and 1 ml to help with serving size. Here is the breakdown by strength of the amount of CBD per serving, 1 dropper full: 500mg contains 16mg of CBD per serving 1000mg contains 33mg of CBD per serving 3000mg contains 100mg of CBD per serving
Some states only allow for products infused with CBD, some only allow for high-CBD and low-THC products, while others allow both THC and CBD. To further confuse the American citizenry, some states permit patients the use of CBD, but require that they travel to another state to purchase it. To make sense of this confounding patchwork and to learn about each individual state’s CBD laws, read the Weedmaps Laws and Regulations page.
Right now, there’s a good chance that you don’t really know what you’re getting from any source. Testing and labeling rules vary by state, but many states that allow legal cannabis also require some kind of testing to verify that the THC and CBD levels listed on the label are accurate. However, this testing is controversial, and results can vary widely between labs, Jikomes said. A study published in March found measurable variations in test results, with some labs consistently reporting higher or lower levels of cannabinoids than others. There are no guarantees that the label accurately reflects what’s in the product. For a 2015 study published in JAMA, researchers tested 75 products purchased in San Francisco, Los Angeles and Seattle and found that only 17 percent were accurately labeled. More than half of the products contained significantly lower levels of cannabinoids than the label promised, and some of them contained only negligible amounts of the compounds. “We need to come up with ways to confidently verify the composition of cannabis products and make this information available to consumers,” Jikomes said.
I couldn’t be more pleased with this product! I have fibromyalgia, sciatica and arthritis in my lower back. My daily pain levels range from 5-8. Since I started using the 500mg tincture, it’s made a tremendous difference! I’m ready to bump up to 1000mg and I can’t wait to see the results. The only negative, its costly for those of us on disability.

[193] N. M. Kogan, E. Melamed, E. Wasserman, B. Raphael, A. Breuer, K. S. Stok, R. Sondergaard, A. V. Escudero, S. Baraghithy, M. Attar-Namdar, S. Friedlander-Barenboim, N. Mathavan, H. Isaksson, R. Mechoulam, R. Müller, A. Bajayo, Y. Gabet, and I. Bab, “Cannabidiol, A Major Nonpsychotropic Cannabis Constituent, Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts,” Journal of Mineral and Bone Research 30, no. 10 (October 2015): 1905–1913.


Hemp oil can come from the flower, leaves, stock or seeds. If it comes from the seed there are no cannabinoids found. If it comes from the rest of the plant cannabinoids are found. Hemp extract usually refers to either CBD or oil from the stock, flower, or leaves. Our Virgin cannabis sativa hemp oil is a hemp seed oil, and our Premium hemp oil products, have hemp oil from the stem of the plant (which is listed in milligrams on the bottle) It also has hemp seed oil in the bottle to act as a carrier oil. Our Hemp seed oil is a cold pressed seed oil, and our Premium hemp oil that comes from the stem is Co2 extracted.
While research into the effects of CBD on specific conditions is important, a broader perspective on the relationship between CBD and the human body is necessary to understand how this unique compound works. Interestingly, many of the conditions that are supposedly helped by CBD have no well-understood cause, from acne to Alzheimer’s disease. However, one of the few common denominators between these conditions is the involvement of the endocannabinoid system (ECS) in their causes.
I have crohns dibeates 2 stage kidney failure I take 6000 mg of chemicals a day when I get a flair l might lose a lot of blood I've had fistula surgery once darn mean killed me 2 more just gut surgerys little bit of gut removed I tease my gut doctor he schoold just put in a zipper any way I'm looking for something natural to try for pain also where I live if you get caught automatic life so the delima begins how much would any one suggest starting out with thanks for your time also compared to most of the folks mine seems like a minor problem on this site but I would appreciate some advice I hope all you folks have good lives and remember god always loves you even though sometimes you think he may have forgotten you
Cannabidiol, or CBD for short, is a natural phyto-cannabinoid (or plant-based chemical compound) found in cannabis plants, including hemp and marijuana. Unlike other cannabinoids — namely tetrahydrocannabinol, or THC — CBD does not produce any psychoactive effects, and will actually counteract these effects to a degree. CBD will induce feelings of sleepiness; for this reason, it can be an effective soporific for people who struggle to fall and/or remain asleep due to insomnia and other sleep disorders. 

Dispensaries: In states where marijuana is legal for recreational use, dispensaries are a common sight. They are much rarer in states with more restrictions. In states that permit the use of medical marijuana, hemp-based CBD oils do not normally require a prescription but marijuana-based oils do. Like brick-and-mortar locations, dispensaries offer more customer service. However, as noted, this may not be an option depending on the buyer’s state of residence. Also, CBD oil prices tend to be significantly higher at dispensaries.
Naturally, scientists wanted to see if CBD oil had any anticancer properties. As a result, they performed several animal studies using it. However, it should be noted that the findings don’t fully apply to humans. In fact, they merely suggest what possible effects CBD might have when it comes to dealing with cancer. With that in mind, additional human studies would help conclude if CBD oil has an effect on cancer cells in humans.
I bought this after hearing about it on Menopause Moment podcast. I was reluctant at first. Most doctors told me take hormones or just deal with hot flashes. After hearing how the podcaster had 80 less hot flashes with MedTerra CBD oil I had to try it. After receiving the 500 mg tincture and taking just 0.25 of the dropper twice aa day morning and night I am a staunch believer. My hot flashes have virtually disappeared and I was plagued by them. CBD oil has relieved 80 or more of my hot flashes. It took about week of consistent routine before I noticed a full affect but I am duly impressed and will be buying more MedTerra CBD oil in the future. Ive akso noticed more energy my mood has elevated and I feel all around better and a little more human again. It also worked on middle age general achiness. Tasteless easy to use and great quality. Wish everyone knew about MedTerras excellent quality and their CBD oils excellent benefits. This has made menopause so much more bearable Thank you for creating such a great organic pesticide free product MedTerra. .
It should also be noted that, because CBD oil is mostly unregulated, products may be incorrectly labeled. To that end, a study published in the Journal of the American Medical Association in 2017 found that nearly 70 percent of all CBD products sold online are mislabeled and that a number of products contain a significant amount of THC. Since THC can aggravate anxiety and make your heart beat faster than normal, it’s possible that using CBD oil that contains THC might make your anxiety worse.

Cannabinoids, including cannabidiol (CBD), work by mimicking natural endocannabinoids like anandamide (described above) in the body. Endocannabinoids are part of a complex messaging system in the body called the endocannabinoid system. The endocannabinoid system oversees or regulates parts of the nervous system, endorphins, immune system functions, hormones, mood and emotions, metabolism, and many other chemical messengers in the body.
CBD, or cannabidiol, is a cannabinoid found in the hemp plant. As we’ve discovered more about the human species as well as the plants that we’ve learned of the immense health value that CBD brings to the table. It has quickly become a staple supplement for millions who seek a natural alternative to dangerous pharmaceuticals, alien to nature’s perfect remedies.
Plus CBD Oil™ products come in a variety of flavors and concentrations to suit your preferences. If you are considering CBD oil for your health, as with any supplement, we encourage you to speak with your physician and dive into the research to learn more about this promising phytonutrient. Plus CBD Oil™ products come in a variety of flavors and concentrations to suit your preferences. We at Plus CBD Oil™ are proud of our innovative selection of products.
In the past several years however, public interest in CBD has skyrocketed based on claims — largely unsubstantiated through good clinical research thus far — that it may be a kind of cure-all miracle drug, with therapeutic effects ranging from pain relief to eradicating cancer. In fact, while CBD research has been limited due to federal restrictions, preliminary evidence does suggest that it might help with psychiatric conditions like anxiety disorders (note that while many people claim that CBD is not “psychoactive,” it’s potential as an anxiolytic medication suggests otherwise) and  recent randomized, controlled clinical trials suggest a possible role in the treatment of psychotic disorders.2,3 In 2018, the Food and Drug Administration (FDA) approved Epidiolex, a form of CBD manufactured by GW Pharmaceuticals, for the treatment of rare forms of pediatric epilepsy (see my blogpost "Cannabis for Kids: Can Marijuana Treat Childhood Seizures?").
Taste can be a sign of value, too. Poor quality oils will have a very unpleasant chemical taste, and they can cause significant burning to mouth tissues. A good quality product should be smooth and not cause significant burning. Interestingly, the best quality products are associated with a distinct cannabis taste, indicating that the full spectrum of chemical components (with trace levels of THC) are present.
Cannabinoids are facilitative of the process of bone metabolism—the cycle in which old bone material is replaced by new at a rate of about 10 percent per year, crucial to maintaining strong, healthy bones over time. CBD in particular has been shown to block an enzyme that destroys bone-building compounds in the body, reducing the risk of age-related bone diseases like osteoporosis and osteoarthritis. In both of those diseases, the body is no longer creating new bone and cartilage cells. CBD helps spur the process of new bone-cell formation, which is why it has been found to speed the healing of broken bones and, due to a stronger fracture callus, decrease the likelihood of re-fracturing the bone (bones are 35–50 percent stronger than those of non-treated subjects).[193]
Hi Colleen, it's almost a year later and I'm wondering how you're doing. I'm experiencing a recurrence of Stage 3 ovarian, originally diagnosed in 2011. I've decided to get some chemo, not sold on another 6 cycles though. As a new MMJ patient, I'm still going to go through with Rick Simpson Oil (THC+CBD,) and I just joined a program with my local dispensary to get CBD capsules for $2 each when I order them at least 30 at a time. I hope you're doing well!! I'm off to do more research on dosing. **NOTE: If you have ANY experience with CBD treatment of ovarian cancer, PLEASE respond. Thank you!!
California’s legalization spurred Dr. Geoffrey Guy and Dr. Brian Whittle to found GW Pharmaceuticals, a company that would utilize clinical trials to unpack various cannabinoid formulations as potential therapies with the overriding focus of developing what would later be known as Sativex (Nabiximols). This oral mucosal spray was made up of CBD and THC in a 1:1 ratio and successfully combated neuropathic pain, spasticity, overactive bladder, and symptoms of multiple sclerosis.
Your post indicates a difference between hemp oil (which you said is from seeds) and hemp extract (which there doesn’t seem to be much information about on your site) and that your all recommend hemp extract. The links you post for hemp extract link to products labeled at hemp oil and as containing hemp oil. My question: are your products derived from hemp seeds, full plant extraction, or a cbd isolation/extraction process? Thanks!!
Note that the original federal distinction between hemp and marijuana in the Controlled Substances Act of 1970 was intended to separate useful industrial applications of hemp from the potentially hazardous smoking or other consumption of marijuana and its constituents for recreational purposes. In the fine print of the Controlled Substances Act however, exemption of hemp from the definition of marijuana did not include the resin extracted from the mature stalks of plants which might be expected to contain concentrated cannabinoids. While the 2018 Farm Bill passed by a Republican majority US Senate and House of Representatives in order to provide relief to farmers so that they can now grow hemp for industrial applications and apply for grants and insurance to do so, it may not have been intended to provide a new pathway to extract and purify CBD from hemp plants with the intent of large-scale human consumption as a food additive, dietary supplement, or medication. But make no mistake — cannabis companies are excited about and are intending to negotiate just this possibility. We’ll have to see how the FDA and DEA, and in turn federal judges and legislators, respond.
People suffering from other neurological disorders might also benefit from using CBD oil as part of their treatment. Several studies involving Parkinson’s disease showed that participants slept better after treatment. Furthermore, their overall quality of life increased. Amazingly, CBD also showed positive benefits in treating or preventing Alzheimer’s disease. As CBD lowers inflammation, it helps prevent nerves from degenerating. During one study, scientists used mice with the genetic predisposition for Alzheimer’s disease. They found that CBD helped by preventing the mice’s cognitive decline.

As noted in the report by Booth, Page, and Bohlmann, various strains of cannabis plants produce terpenes differently. Commonly, hemp plants contain less terpene-rich resin than marijuana plants. The amount of resin found in hemp plants, however, does not affect the quality of CBD that we obtain from them. In fact, hemp plants are a far better source of CBD than marijuana plants.
As noted in the report by Booth, Page, and Bohlmann, various strains of cannabis plants produce terpenes differently. Commonly, hemp plants contain less terpene-rich resin than marijuana plants. The amount of resin found in hemp plants, however, does not affect the quality of CBD that we obtain from them. In fact, hemp plants are a far better source of CBD than marijuana plants.
What makes CBD so appealing is that it’s non-intoxicating, so it won’t get you high, though it “is technically psychoactive, because it can influence things like anxiety,” Jikomes said. Although much of the marketing blitz around CBD centers on the fact that you can take it without getting stoned, there isn’t much research looking at the effects of CBD when used in isolation, with a couple of exceptions. One is the use of CBD to treat seizures: CBD is the active ingredient in the only cannabis product that the Food and Drug Administration has signed off on — a drug called Epidiolex, which is approved for treating two rare forms of epilepsy. Animal models and a few human studies suggest that CBD can help with anxiety, but those are the only conditions with much research on CBD in isolation.
Along with THC, cannabidiol (CBD) is one of more than a hundred “phytocannabinoids” contained in the Cannabis plant. Relative to the amount of THC in marijuana grown for recreational use, the amount of CBD is trivial, with the proportion of THC to CBD increasingly widening over the past several decades.1 The breeding of cannabis strains with more THC and less CBD has occurred in response to recreational consumer demand. More THC means more of a “high,” whereas CBD — which can oppose some of the effects of THC — doesn’t have any euphoric effects and may interfere with the high produced by THC. So, for the most part, CBD-laden marijuana has not been what recreational users are looking for.
In recent years however, with increasing state legalization of cannabis and a burgeoning multibillion-dollar cannabis industry, US farmers have increasingly lobbied to remove federal restrictions against growing hemp. The Agricultural Act of 2014 (aka the 2014 Farm Bill) signed by President Obama set the stage for this to happen by loosened restrictions on hemp, allowing universities and state agriculture departments to grow it for research purposes. Now the 2018 Farm Bill opens those gates more broadly, allowing licensed farmers to grow hemp and transport it across state lines based on agreements and regulations to be established between states and the federal government.

So even though hemp oil and CBD oil come from the same genus and species (Cannabis sativa), hemp oil is derived from a strain that has a very low cannabinoid count (more on that later). CBD oil, on the other hand, is derived from the strains you can find in your local dispensary. Many growers refer to the hemp plant as a cousin of the plant that produces your Fruity Pebbles and your Yoda OG.
CBD has positive implications in a vast number of illnesses and has been shown to boost general health, hair and skin.  Research isn’t conclusive here, although it is strong, and in the coming years, we are expecting to see more and more evidence.  THC, on the other hand, can benefit other disorders but comes with drawbacks, such as the feelings of being high and possible induction of feelings of anxiety and paranoia and more.

The trace amount of THC in CBD oil (<0.3%) is not enough to trigger most drug tests as being positive for THC. You would need to consume about 1000-2000 mg per day of CBD to fail a drug test for THC if the employer is testing to SAMHSA guidelines (Substance Abuse and Mental Health Services Administration). If you are tested regularly and taking high doses of CBD, and you are concerned about the very low risk of a positive drug test for THC associated with using hemp-derived products, you could opt to use purified CBD, which does not contain anything but CBD. Just know that purified CBD doesn’t provide the same spectrum of benefits as CBD oil.


Sativex, a cannabis plant–derived oromucosal spray containing equal proportions of THC and CBD, has been approved in a number of countries for use to treat specific types of pain. Numerous randomized clinical trials have demonstrated the safety and efficacy of Sativex for treatment of central and peripheral neuropathic pain, rheumatoid arthritis, and cancer pain. [386]

As the brain ages, the creation of new neurons slows down significantly. In order to maintain brain health and prevent degenerative diseases, new cells need to be continuously created. A 2008 study showed that low doses of CBD- and THC-like cannabinoids encouraged the creation of new nerve cells in animal models, even in aging brains.[192] CBD also benefits the brain by helping to prevent other nerve-related diseases like neuropathy and Alzheimer’s disease.
Taste can be a sign of value, too. Poor quality oils will have a very unpleasant chemical taste, and they can cause significant burning to mouth tissues. A good quality product should be smooth and not cause significant burning. Interestingly, the best quality products are associated with a distinct cannabis taste, indicating that the full spectrum of chemical components (with trace levels of THC) are present.

I have idiopathic peripheral neuropathy ... the only thing they found that would work is lyrica. I picked up some CBD oil yesterday morning. I am prescribed to take 75 mg of lyrica 3x per day. I took one yesterday morning and have only used the CBD oil since. I bought the Koi brand, flavored, 250 MG. I used a full dropper yesterday late morning and a full dropper yesterday late afternoon. I used it once today (one full dropper) and I am amazingly pain free.


....but it sure isn't the only game in town. Tip of the hat to you for seeing the coming 'fad" of CBD wellness. But like many of the folks who genuflect at the altar of FDA approval you missed the fact that the teeming masses you see from your ivory tower will believe what they see with their own two eyes. It isn't going to need advertising other than word of mouth.
Although anxiety disorders are generally treated with psychotherapy, medication, or a combination of the two, many people opt to forgo these standard approaches and self-treat with products like CBD oil. According to a survey published in Cannabis and Cannabinoid Research in 2018, almost 62 percent of cannabidiol users reported that they used CBD to treat a medical condition, with the top three conditions being pain, anxiety, and depression.
For legal reason we can’t claim that any of our products can cure or treat any type of Cancer. If you are looking for a CBD oil, I would direct you towards are Premium hemp oil drops or softgels. Our Premium hemp oil products contain full spectrum hemp oil. Full spectrum hemp oil and CBD oils are equivalent because they both contain the cannabinoids that are used to assist with pain, inflammation, stress, anxiety, and sleep. If you feel you good benefit from our premium hemp oil products then here is a link to them: https://zatural.com/collections/hemp-oil-products/products/cannabis-sativa-hemp-oil-drops
In the past several years however, public interest in CBD has skyrocketed based on claims — largely unsubstantiated through good clinical research thus far — that it may be a kind of cure-all miracle drug, with therapeutic effects ranging from pain relief to eradicating cancer. In fact, while CBD research has been limited due to federal restrictions, preliminary evidence does suggest that it might help with psychiatric conditions like anxiety disorders (note that while many people claim that CBD is not “psychoactive,” it’s potential as an anxiolytic medication suggests otherwise) and  recent randomized, controlled clinical trials suggest a possible role in the treatment of psychotic disorders.2,3 In 2018, the Food and Drug Administration (FDA) approved Epidiolex, a form of CBD manufactured by GW Pharmaceuticals, for the treatment of rare forms of pediatric epilepsy (see my blogpost "Cannabis for Kids: Can Marijuana Treat Childhood Seizures?").
Linked to diet and lifestyle, atherosclerosis is common in developed Western nations and can lead to heart disease or stroke. It is a chronic inflammatory disorder involving the progressive depositing of atherosclerotic plaques (immune cells carrying oxidized LDL or low-density lipoproteins). A growing body of evidence suggests that endocannabinoid signaling plays a critical role in the pathology of atherogenesis.[181] The condition is now understood to be a physical response to injuries in the arterial walls’ lining, caused by high blood pressure, infectious microbes, or excessive presence of an amino acid called homocysteine. Studies have demonstrated that inflammatory molecules stimulate the cycle leading to atherosclerotic lesions.[182] Existing treatments are moderately effective though carry numerous side effects. CB2 receptors triple in response to inflammation, allowing anandamide and 2-AG, the body’s natural cannabinoids, to decrease inflammatory responses. The CB2 receptor is also stimulated by plant-based cannabinoids.[183]
Among all of the experts, there's no hard and fast rule on how long it stays in your system. Again, if you've had pure CBD, it shouldn't matter when you had it last since it won't show up in urine tests. If you've had CBD and THC, the Colorado Pot Guide suggests you'll be positive on a drug test within seven days of use. Now, if you take in a lot of THC, you could test positive for a month or more.
Buying CBD OIL has never been easier.  Since CBD Oil from the Hemp plant does not contain unlawful measures of THC, it is legitimate in every one of the 50 states. This is imperative to individuals everywhere throughout the US who need CBD however can’t get it locally. What’s more, legitimate CBD is accessible for home conveyance in every one of the 50 states meaning numerous individuals don’t need to move to a state with sanctioned Medical Marijuana. Additionally, in states where medicinal weed is lawful, buyers utilizing this hemp plant type of CBD don’t need to obtain a medical marijuana card.
Royal Queen Seeds CBD Oil offers a convenient, discreet and quick way to dose yourself with a bit of CBD, no matter your situation or where you are. All of our CBD oil is created using organically grown hemp sourced from right here in Europe, extracted using the latest CO² techniques. It means our oil is 100% natural, offering pure and strong CBD. All you need to do as drop you dose under your tongue or in your food, and away you go!
The legality of CBD in the US varies from state to state, but at the federal level, CBD is mysteriously classified as a Schedule I drug despite its sourcing. According to the federal government, Schedule I drugs are substances or chemicals with no currently accepted medical use and a high potential for abuse. Other Schedule I drugs include heroin, LSD, marijuana, and ecstasy. However, CBD can be purchased as a dietary supplement throughout the country despite the FDA’s official stance that CBD isn’t a supplement. The landscape of CBD legality in the US is exactly as confusing as it reads; that squirrely, perplexing itch at the back of your brain is cognitive dissonance, and it’s an entirely normal reaction.
Disclaimer: This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor’s advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual results will vary. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited By Law.
Leafly is the world’s largest cannabis information resource, empowering people in legal cannabis markets to learn about the right products for their lifestyle and wellness needs. Our team of cannabis professionals collectively share years of experience in all corners of the market, from growing and retail, to science and medicine, to data and technology.
CBD has been in the news before, as a possible treatment for epilepsy. Research is still in its early days. Researchers are testing how much CBD is able to reduce the number of seizures in people with epilepsy, as well as how safe it is. The American Epilepsy Society states that cannabidiol research offers hope for seizure disorders, and that research is currently being conducted to better understand safe use.
Since marijuana is illegal on a federal level, but legal on a state-by-state basis, growers and cannabis businesses cannot legally transport cannabis products across state lines. Some companies that make CBD products — usually supplied in the form of lotion, oils, and pills — have done so anyway, based on the claim that CBD derived from hemp can be classified as botanical extract and a dietary supplement. But over the past few years, the FDA has issued numerous “cease and desist” letters to companies produce cannabis products warning them not to make health-related CBD claims and making clear that it does not consider CBD a dietary supplement.
×